Path of Exile 2: Trial of the Sekhemas – A Comprehensive Guide to Sanctum Runs

Path of Exile 2 introduces an innovative endgame system called the Trial of the Sekhemas, drawing inspiration from the original game’s Sanctum mechanic while introducing unique strategic elements. This comprehensive analysis covers the complete methodology behind achieving exceptional returns through 20 consecutive trial completions.

The Trial of the Sekhemas operates as a self-contained league mechanic that doesn’t require specific Atlas passive tree investments. This independence makes it accessible to players at various progression stages, though strategic planning remains crucial for maximizing outcomes.

Unlike traditional mapping content, this trial emphasizes tactical decision-making where players navigate interconnected rooms, manage relic synergies, and optimize encounter selections to amplify rewards. Our data-driven approach reveals consistent profit patterns and optimal pathing strategies.

Building an effective relic configuration requires balancing offensive capabilities, economic advantages, and strategic information. The following setup proved optimal across our 20-run sample:

1. Boss Damage Enhancement Relics

Four specialized relics dramatically increase damage output against boss encounters: the Regicidal Tapestry Relic of Charity, Regicidal Tapestry Relic of Merit, Regicidal Amphora Relic of Clairvoyance, and Regicidal Amphora Relic of Charity. These provide approximately 60-80% increased boss damage collectively, significantly reducing encounter times.

2. Merchant Optimization Relics

• 21% reduced merchant prices achieved through three synergistic relics: Regicidal Tapestry Relic of Charity, Regicidal Amphora Relic of Charity, and Venerable Tapestry Relic of Charity.

• Two additional merchant choices unlocked via the Plentiful Tapestry Relic of Merit.

3. Strategic Information Relics

Room reveal capabilities through the Regicidal Amphora Relic of Clairvoyance provide critical pathing intelligence, allowing avoidance of detrimental encounters and targeting high-value rooms.

4. Defensive Stabilization Relics

Resistance maintenance handled by the Regicidal Tapestry Relic of Merit and Plentiful Tapestry Relic of Merit to ensure survival against elemental damage spikes.

Pro Tip: Avoid stacking redundant relic effects – each additional identical modifier provides diminishing returns. Focus instead on creating a balanced portfolio that addresses all critical trial aspects.

The trial presents players with complex decision trees and challenging encounters. Our analysis identified several consistent patterns and optimization opportunities across the complete run series.

1. Relic Acquisition Patterns

Grand Spectrums and unique relics appeared consistently throughout the trial sequence, with notable acquisitions including:

• Grand Spectrum (Spirit): Highly sought-after relics commanding premium market prices.

• Desperate Alliances: Multiple specimens discovered, each valued at three divine orbs.

• Medium and Large Relics: Boss damage enhancements and other powerful modifiers with significant resale value.

2. Chest Prioritization Strategy

• Gold Spectrum Cache: Consistently provide Grand Spectrums, representing some of the highest-value encounters available.

• Royal and Royal Cache: Generate valuable jewels and unique items with consistent demand.

• Mysterious Cache: Offer randomized rewards including currency items, though with higher variance than specialized caches.

3. Boss Encounter Tactics

• Successfully confronted all major bosses across 20 consecutive completions.

• Accumulated diverse loot including Divine Orbs, specialized relics, and Path of Exile 2 exclusive unique items.

Common Mistake: Many players undervalue Mysterious Caches – while inconsistent, they occasionally provide exceptional returns that justify the risk.

The trial generated substantial profits through both direct loot acquisition and supplementary service offerings. Our detailed accounting reveals multiple revenue streams and their respective contributions.

1. Loot Valuation Breakdown

• Total loot valuation: 52 divines from relics, currency, and specialized items.

• Average profit per individual run: 2.6 divines.

• Key relic contributions included:

• Grand Spectrum (Spirit): Valued at two divines each.

• Desperate Alliances: Seven acquired specimens worth 21 divines collectively.

• Additional unique relics: Estimated collective value of 25 divines.

2. Carry Service Economics

• Successfully guided 40 players through complete ascendancy acquisition processes.

• Service charges ranged between 30-35 exalts per completion, contributing an additional 15.2 divines to overall profits.

3. Overall Profit Metrics

• Combined earnings: 67.2 divines.

• Average profit per run including service revenue: 3.4 divines.

Advanced Insight: The carry service market demonstrates consistent demand, particularly during league start periods when players seek rapid power progression.

Maximizing efficiency and profitability in the Trial of the Sekhemas requires implementing sophisticated strategies beyond basic relic selection and pathing.

1. Gear Optimization Principles

• High-movement speed equipment like Temporalis boots reduces completion times by 30-40%, directly increasing profit per hour metrics.

• Specialized single-target builds excel in boss encounters, though balanced approaches handle diverse room types more consistently.

2. Path Selection Logic

• Prioritize Spectrum, Royal, and Timeless caches for their predictable high-value returns.

• Mysterious caches warrant consideration for variance plays, particularly when other options appear suboptimal.

3. Risk Management Protocols

• Avoid unnecessary relic accumulation that complicates inventory management without providing meaningful benefits.

• Develop contingency plans for challenging room combinations that might otherwise end runs prematurely.

Expert Technique: Map your intended route before committing to room selections – this prevents costly backtracking and optimizes reward density.

For players seeking to expand their gameplay knowledge, our Class Guide provides complementary strategic frameworks applicable across different game modes.

The Trial of the Sekhemas represents one of Path of Exile 2’s most rewarding endgame activities when approached with proper preparation and strategic execution.

Players can achieve consistent high returns by implementing the relic configurations, chest prioritization strategies, and service offerings detailed in this analysis. The mechanic’s self-contained nature makes it ideal for focused farming sessions without extensive external investment requirements.

Future optimization opportunities include experimenting with alternative relic combinations, developing specialized builds for specific trial aspects, and expanding service offerings to capitalize on market demand.

For comprehensive gameplay guidance beyond this specific mechanic, explore our Complete Guide covering broader game systems and progression strategies.

Whether your focus centers on loot acquisition, challenge completion, or community service provision, the Trial of the Sekhemas delivers engaging content with substantial reward potential.

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